*Correspondence to: Quang Huan Le, Institute of Biotechnology, Vietnam Academy of Science and Technology, Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
Received: Jan 23, 2021; Accepted: Feb 07, 2021; Published: Feb 15, 2021
Citation: Nguyen TQ (2021) Study on Screening Vietnamese Herbs with Antiviral Activity to Create Products to Support Treatment of some Diseases Caused by RNA-virus. J Nanomed Nanotech Nanomat. 2: 107
Copyright: ©2021 Nguyen TQ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Using information technology and traditional oriental medicine research, we have screened 5 Vietnamese herbs that contain active ingredients with antiviral effects. Andrographis paniculata, Syzygium aromaum, Zingiber officinale Rose, Houttuynia cordata, Glycyrrhiza uralensis Fisch. The active ingredients in herbs are extracted by ultrasound in a water-ethanol solvent system and made in the form of a nanometer complex, then mixed in specified proportions to form the product. The product was evaluated cytotoxicity by MTT (3-(4,5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) assay and evaluated the growth inhibition effect of H5N1 virus. Result: The complex of active ingredients in the composition has the nanometer size, the main size is 443 nm, the zeta potential is -11.9 mV. The inhibitory activity of the H5N1 virus was dose-dependent, and a concentration of 3 mg/mL completely inhibited the growth of the H5N1 virus in the erythrocyte agglutination test.
Keywords: Antiviral activity; Nanomedicine; Nanoparticle; Vaccine; COVID-19; SARS CoV-2
